منابع مشابه
Cytokinesis: a logical GAP
Two complexes localize to the central spindle and regulate completion of cytokinesis: one, centralspindlin, contains a kinesin-like protein and a Rho-family GAP; the second contains Aurora B kinase. Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin.
متن کاملCytokinesis: GAP Gap
The central spindle regulates cleavage furrow formation and cytokinesis and is composed of antiparallel microtubules bundled by microtubule-associated proteins and kinesin motors. One key protein in the central spindle is a Rho family GTPase-activating protein, CYK-4/MgcRacGAP, whose target is the subject of two new studies that arrive at divergent models.
متن کاملClosing the Gap: Phenomenology and Logical Analysis
IT IS WITH BOTH PRIDE AND HESITATION THAT I AGREED TO WRITE THIS ARTICLE ON phenomenology and logical analysis. John Searle and Bert Dreyfus are for me two of the paradigm figures of contemporary philosophy, so I am extremely proud to have been offered the opportunity to engage with their work. The editors of The Harvard Review of Philosophy, it seems to me, have shown a keen sense of what is d...
متن کاملA logical analysis of the Drosophila gap-gene system.
This manuscript focuses on the formal analysis of the gap-gene network involved in Drosophila segmentation. The gap genes are expressed in defined domains along the anterior-posterior axis of the embryo, as a response to asymmetric maternal information in the oocyte. Though many of the individual interactions among maternal and gap genes are reasonably well understood, we still lack a thorough ...
متن کاملCYK-4: A Rho Family GTPase Activating Protein (GAP) Required for Central Spindle Formation and Cytokinesis
During cytokinesis of animal cells, the mitotic spindle plays at least two roles. Initially, the spindle positions the contractile ring. Subsequently, the central spindle, which is composed of microtubule bundles that form during anaphase, promotes a late step in cytokinesis. How the central spindle assembles and functions in cytokinesis is poorly understood. The cyk-4 gene has been identified ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00521-9